Haemoglobin Belfast 15 (A12) Tryptophan->Arginine: A New Unstable Haemoglobin Variant

New 13-Chain Variant of Haemoglobin A Found in Combination with Haemoglobin S

During a routine study of the parents of a 3month-old Jamaican child with the sickle-cell trait the father was found to have a haemoglobin electrophoretic pattern identical to that of homozygous sickle-cell disease. Because he was perfectly well and had no haematological abnormalities detailed studies of his haemoglobin constitution were undertaken. These indicate that he is heterozygous for bo...

The clinical features of unstable haemoglobin disease.

Haemoglobin Osu - Christiansborg : A New - chain Variant of Haemoglobin A ( , 352 ( D 3 ) Aspartic Acid - - Asparagine ) in Combination with Haemoglobin S

A 63-year-old man, a member of the Ga tribe from the Osu-Christiansborg area in Accra was examined for hypertension. On incubation with 2% sodium metabisulphate his red cells readily sickle. Only two haemoglobin bands were demonstrated by paper electrophoresis at pH 8-9 (Cradock-Watson, Fenton, and Lehmann, 1959) and starch gel electrophoresis atpH 8-6 (Poulik, 1957), a minor one corresponding ...

Haemoglobin J Tongariki (alpha-115 alanine--aspartic acid): the first new haemoglobin variant found in a Pacific (Melanesian) population.

In the course of a medico-genetic-anthropological investigation in I963 of the population of the island of Tongariki, in the Shepherd group of the New Hebrides, a haemoglobin variant was detected with a mobility which was greater than that of normal Hb on electrophoresis at alkaline pH, both by starch gel and by paper electrophoresis. The variant was found in this first survey in 17 of 228 pers...

Unstable haemoglobin Köln disease in members of a Malay family.

A group of unstable haemoglobins associated with congenital nonspherocytic haemolytic anaemia has recently been recognized. They are characterized by the instability of the haemoglobin solutions and by being heat labile. Contrary to most known abnormal haemoglobins reported to date, their presence in the blood is not always easy to demonstrate by electrophoretic methods. In the red blood cells ...